Thomas Jefferson famously wrote that the earth belongs to the living. His letter to James Madison is often quoted for the proposition that we should not be bound to the 'dead hand of the past', suggesting that the Constitution should instead be interpreted as a living, breathing document. Less well-known is Madison's response, in which he said the improvements made by the dead - including the U…
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for …
This book contains extended and revised versions of a set of selected papers from two events organized by the Euro Working Group on Decision Support Systems (EWG-DSS), which were held in Toulouse, France and Barcelona, Spain, in June and July 2014. Overall, 8 papers were accepted for publication in this edition after a rigorous review process through at least three internationally known experts…
This book constitutes the refereed proceedings of the First International Conference on Decision Support Systems Technology, ICDSST 2015, held in Belgrade, Serbia, in May 2015. The theme of the event was "Big Data Analytics for Decision-Making" and it was organized by the EURO (Association of European Operational Research Societies) working group of Decision Support Systems (EWG-DSS). The eight…
This book offers a thorough review and explanation of decision support methods and tools, and shows how these are best applied to a wide range of situations in the practice of sustainable forest management. The goal is to provide both students and working forest managers a toolbox of methods covering most of the decision situations encountered in practice. The first chapter introduces basic con…
This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, a…
Based on theory and an empirical survey, Philipp K. Berger measures the amount of fear for different groups of entrepreneurs. He draws parallels to Prospect Theory revealing the components of fear and shows, that entrepreneurial fear is a rather rational subconscious evaluation of the situation. Furthermore, he identifies the root causes of this fear – the fear of failure – and the underlyi…
Water balance studies for large and small river basins are the subject of this book. Here, the specific focus is on the soil and water assessment tools (SWAT) model coupled with geographic information system (GIS) remote sensing data for a comprehensive study. Some books available in the market provide an overview of different hydrological models for water balance but not specifically for the S…
Japan's savings are among the highest in the world, and these high rates have played a valuable role throughout the post-war period. However, over the next several decades, Japan's population will be ageing rapidly. Will this lower Japanese savings rates? Using up-to-date financial and demographical data, author Robert Dekle finds that the answer to this question is an emphatic 'yes'. Understa…
Spiritual Shakespeares is the first book to explore the scope for reading Shakespeare spiritually in the light of contemporary theory and current world events. Ewan Fernie has brought together an exciting cast of critics in order to respond to the ‘religious turn’ in recent literary theory and to the spiritualized politics of terrorism and the ‘War on Terror’. Exploring a genuinely n…