Appropriate mathematical tools and methodologies are critical for ensuring robust and reliable computational model predictions based on medical and healthcare data in the era of the digital health revolution (Duggal et al., 2018). Patient-specific approaches are being increasingly pursued, with simulations benchmarked by clinical data (e.g., brain activity recordings; Breakspear, 2017) obtain…
Cancer care delivery refers to the multiple layers of the health care system that interact to affect outcomes for patients with cancer and the quality of that care. The factors included in the care delivery system that potentially alter outcomes include social dynamics, financing systems, organizational structures and processes, health technologies, provider and individual behaviors. Because wo…
This chapter covers the Civil Procedure topic of Pleading: The Plaintiff‘s Complaint. The chapter takes approximately four class periods to cover in detail. The student is exposed to cases, presented with questions that are designed to both guide class discussion and to help the student focus his reading of the materials, pleadings from cases, and the applicable Federal Rules of Civil Procedure.
The fungal genus Botrytis is the focus of intensive scientific research worldwide. The complex interactions between this pathogen and the plants it infects and the economic importance of the diseases caused by Botrytis (principally grey mould) on more than 1400 species of cultivated plants pre- and post-harvest, render this pathogen of particular interest to farmers, advisers, students and rese…
Provides a comprehensive overview and introduction to the concepts, methodologies, analysis, design and applications of metasynthetic computing and engineering. The author: • Presents an overview of complex systems, especially open complex giant systems such as the Internet, complex behavioural and social problems, and actionable knowledge discovery and delivery in the big data era. • Discu…
This book provides a unified overview of network-on-chip router micro-architecture, the corresponding design opportunities and challenges, and existing solutions to overcome these challenges. The discussion focuses on the heart of a NoC, the NoC router, and how it interacts with the rest of the system. Coverage includes both basic and advanced design techniques that cover the entire router desi…
The book describes how plant biomass can be used as renewable feedstock for producing and further processing various products. Particular attention is given to microbial processes both for the digestion of biomass and the synthesis of platform chemicals, biofuels and secondary products. Topics covered include: new metabolic pathways of microbes living on green plants and in silage; using lig…
This book explores the nature of pregnancy and metabolic syndrome as proinflammatory conditions and explains how pregnancy provides a window of opportunity for preventing the lifelong complications of metabolic syndrome, during which key risk factors can be identified and beneficial dietary changes can be implemented. The book’s opening sections discuss inflammation in the context of pregn…
Stephan Herzig obtained his PhD from the University of Göttingen, Germany, in 1999. Supported by the German Research Foundation DFG he then joined the Salk Institute for Biological Studies, La Jolla, CA, for his postdoctoral training. In 2004, he established an Emmy-Noether and Marie Curie Junior Research Group at the German Cancer Research Center (DKFZ) in Heidelberg, Germany. He became Head …
This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to dis…