This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are des…
This book consists of 23 essays about prominent people and events in the history of respiratory physiology. It provides a first-hand chronicle of the advancements made in respiratory physiology starting with Galen and the beginnings of Western physiology. The volume covers every aspect of the evolution of this important area of knowledge: pulmonary circulation, Boyle’s Law, pulmonary capillar…
This book focuses on pests (insect and mite) and diseases (fungal, bacterial, viral and nematode) in protected horticulture (fruits, vegetables and ornamentals) using physical, cultural, chemical, biological, host resistance, and integrated methods. It opens with chapters describing the setting in which integrated pest and disease control operates, i.e., the greenhouse and its environment. Subs…
This book discusses in detail molecular, mycobiont culture, biomonitoring and bioprospection of lichens, providing insights into advances in different fields of lichenology by applying modern techniques and approaches and examining how their application has enhanced or changed classical approaches. It offers a valuable resource, especially for beginners, students and researchers from different …
Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogeni…
This book introduces a new paradigm in system description and modelling. The author shows the theoretical and practical successes of his approach, which involves replacing a traditional uniform description with a polyphasic description. This change of perspective reveals new fluxes that are cryptic in the classical description. Several case studies are given in this book, which is of interest o…
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within wh…
This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emergin…
Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotype…
Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell…