Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are smal…
The availability of powerful non-invasive neuroimaging techniques has given rise to various studies that aim to map the human brain. These studies focus on not only finding brain activation signatures but also on understanding the overall organization of functional communication in the brain network. Based on the principle that distinct brain regions are functionally connected and continuou…
Machine learning models can automatically discover biomedical research trends and promote the dissemination of information and knowledge. Text feature representation is a critical and challenging task in natural language processing. Most methods of text feature representation are based on word representation. A good representation can capture semantic and structural information.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
Remarkable advances in medical diagnostic imaging have been made during the past few decades. The development of new imaging techniques and continuous improvements in the display of digital images have opened new horizons in the study of brain anatomy and pathology. The field of brain imaging has now become a fast-moving, demanding and exciting multidisciplinary activity. I hope that this textb…
This open access book identifies and discusses biodiversity’s contribution to physical, mental and spiritual health and wellbeing. Furthermore, the book identifies the implications of this relationship for nature conservation, public health, landscape architecture and urban planning – and considers the opportunities of nature-based solutions for climate change adaptation. This transdiscipli…
This contribution book is a collection of reviews and original articles from eminent experts working in the multi- and interdisciplinary arena of biomaterials, ranging from their design to novel uses. From their personal experience, the readers can obtain a stimulating foresight on the potentialities of different synthetic and engineered biomaterials. 21 chapters have been organized to illustra…
A history of UK radionuclide studies reveals pioneering work from George von Hevesy in Manchester (1911) through to modern PET/MR, with key developments including early homemade scanners (Mallard, Mayneord), GFR measurement, radioimmunoassay, SPECT/CT, and advanced brain imaging (FDG, amyloid). Driven by medical physicists and later clinicians, the field progressed from tracer studies (I-131, T…
This Open Access Book contains reports on the situation of people in the second half of life during the first year of the Covid-19 pandemic. The analyses are based on the German Ageing Survey (DEAS) and they provide insights on four main areas of life: income and work, subjective health and well-being, social support and loneliness as well as societal participation. This book is useful for scie…