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Introduction to Polyphasic Dispersed Systems Theory: Application to Open Syst…
This book introduces a new paradigm in system description and modelling. The author shows the theoretical and practical successes of his approach, which involves replacing a traditional uniform description with a polyphasic description. This change of perspective reveals new fluxes that are cryptic in the classical description. Several case studies are given in this book, which is of interest o…
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- ISBN/ISSN
- 978-3-319-27853-7
- Collation
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ABC Transporters - 40 Years on
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within wh…
- Edition
- Ed. 1
- ISBN/ISSN
- 978-3-319-23476-2
- Collation
- XIV, 376
- Series Title
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- Call Number
- 574.192 ABC a
Genotoxicity and Carcinogenicity Testing of Pharmaceuticals
This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emergin…
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- ISBN/ISSN
- 978-3-319-22083-3
- Collation
- X, 206
- Series Title
- -
- Call Number
- 616.9 GEN
Genomic Instability and Cancer Metastasis
Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotype…
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- ISBN/ISSN
- 978-3-319-12135-2
- Collation
- X, 247
- Series Title
- -
- Call Number
- 616.9 GEN
Real-Time Monitoring of Cancer Cell Metabolism for Drug Testing
Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell…
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- ISBN/ISSN
- 978-3-658-10161-9
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- -
- Series Title
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- Call Number
- 615
Epigenetics Territory and Cancer
This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthro…
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- ISBN/ISSN
- 978-94-017-9639-2
- Collation
- 43 b/w illustrations, 53 illustrations in colour
- Series Title
- -
- Call Number
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Epigenetic Mechanisms in Cellular Reprogramming
The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human…
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- ISBN/ISSN
- 978-3-642-31974-7
- Collation
- 1 b/w illustrations, 19 illustrations in colour
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- Call Number
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Epigenetics - A Different Way of Looking at Genetics
This book presents epigenetics research as a new way of looking at genetics. Topics range from basic epigenetics mechanisms to development of cells and organisms and the biological basis of diseases. In addition the book focuses on immunology and the role of viruses in epigenetics. The last part of the book highlights proteins and peptides as epigenetic modulators.
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- ISBN/ISSN
- 978-3-319-27186-6
- Collation
- 32 b/w illustrations, 9 illustrations in colour
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- -
- Call Number
- -
Introduction to Mathematical Biology: Modeling, Analysis, and Simulations
This book is based on a one semester course that the authors have been teaching for several years, and includes two sets of case studies. The first includes chemostat models, predator-prey interaction, competition among species, the spread of infectious diseases, and oscillations arising from bifurcations. In developing these topics, readers will also be introduced to the basic theory of ordi…
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- ISBN/ISSN
- 978-3-319-29638-8
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- -
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Intrinsically Disordered Proteins Studied by NMR Spectroscopy
This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrin…
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- ISBN/ISSN
- 978-3-319-20164-1
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- -
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