Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design …
Maximizing reader insights into the interactions between game theory, excessive crowding and safety and security elements, this book establishes a new research angle by illustrating linkages between different research approaches and through laying the foundations for subsequent analysis. Congestion (excessive crowding) is defined in this work as all kinds of flows; e.g., road/sea/air traffic…
This is a thorough revision of the 2007 publication, and includes five new chapters and brings all existing chapters completely up to date. There have been many advances in hydropower and renewable technologies since the original publication, and Europe, and particularly Scandinavia, plan many more in the coming years. From a review of the original edition: “… it is important to …
This edited volume is a timely and comprehensive summary of the New Zealand lizard fauna. Nestled in the south-west Pacific, New Zealand is a large archipelago that displays the faunal signatures of both its Gondwanan origins, and more recent oceanic island influences. New Zealand was one of the last countries on Earth to be discovered, and likewise, the full extent of the faunal diversity pres…
This volume reflects “New Trends in Shape Optimization” and is based on a workshop of the same name organized at the Friedrich-Alexander University Erlangen-Nürnberg in September 2013. During the workshop senior mathematicians and young scientists alike presented their latest findings. The format of the meeting allowed fruitful discussions on challenging open problems, and triggered a numb…
This is the first book to compare eight LDFs by different types of datasets, such as Fisher’s iris data, medical data with collinearities, Swiss banknote data that is a linearly separable data (LSD), student pass/fail determination using student attributes, 18 pass/fail determinations using exam scores, Japanese automobile data, and six microarray datasets (the datasets) that are LSD. We deve…
This book demonstrates how to apply modern approaches to complex system control in practical applications involving knowledge-based systems. The dimensions of knowledge-based systems are extended by incorporating new perspectives from control theory, multimodal systems and simulation methods. The book is divided into three parts: theory, production system and information system applications…
This book constitutes the thoroughly refereed post-conference proceedings of the JSAI-isAI 2014 Workshops LENLS, JURISIN, and GABA which took place on November 2014, in Japan. The 26 contributions in this volume were carefully reviewed and selected from 57 submissionsfrom the 3 workshops (LENLS11, JURISIN2014, and GABA2014). LENLS (Logic and Engineering of Natural Language Semantics) is an an…
In this carefully curated collection of essays, editors Jamie Dopp and Angie Abdou go beyond their first collection, Writing the Body in Motion, to engage with the meaning of sport found in Canadian sport literature. How does “sport” differ from physically risky recreational activities that require strength and skill? Does sport demand that someone win? At what point does a sport become an …
This book sheds light on networked control systems; it describes different techniques for asynchronous control, moving away from the periodic actions of classical control, replacing them with state-based decisions and reducing the frequency with which communication between subsystems is required. The text focuses specially on event-based control. Split into two parts, Asynchronous Control fo…