Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under v…
Applied Survival Analysis Using R covers the main principles of survival analysis, gives examples of how it is applied, and teaches how to put those principles to use to analyze data using R as a vehicle. Survival data, where the primary outcome is time to a specific event, arise in many areas of biomedical research, including clinical trials, epidemiological studies, and studies of animals. Ma…
This volume is a unique combination of papers that cover critical topics in biostatistics from academic, government, and industry perspectives. The 6 sections cover Bayesian methods in biomedical research; Diagnostic medicine and classification; Innovative Clinical Trials Design; Modelling and Data Analysis; Personalized Medicine; and Statistical Genomics. The real world applications are in cli…
This book addresses the application of statistical techniques and methods across a wide range of disciplines. While its main focus is on the application of statistical methods, theoretical aspects are also provided as fundamental background information. It offers a systematic interpretation of results often discovered in general descriptions of methods and techniques such as linear and non-line…
This book is aimed at a wide range of readers who lack confidence in the mathematical and statistical sciences, particularly in the fields of Agriculture, Veterinary, Fishery, Dairy and other related areas. Its goal is to present the subject of statistics and its useful tools in various disciplines in such a manner that, after reading the book, readers will be equipped to apply the statistical …
This book brings the power of multivariate statistics to graduate-level practitioners, making these analytical methods accessible without lengthy mathematical derivations. Using the open source, shareware program R, Professor Zelterman demonstrates the process and outcomes for a wide array of multivariate statistical applications. Chapters cover graphical displays, linear algebra, univariate, b…
This study describes the fundamentals of assessing the vulnerability of coral islands, as well as environmental management and resource exploitation. Using seabird subfossils, such as bones, guano, eggshells etc., which have been well preserved on the Xisha Islands in the South China Sea, the author identifies the influences of climate change and human activity on seabird populations and diets.…
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned edit…
The rapidly progressing digital revolution is now touching the foundations of the governance of societal structures. Humans are on the verge of evolving from consumers to prosumers, and old, entrenched theories – in particular sociological and economic ones – are falling prey to these rapid developments. The original assumptions on which they are based are being questioned. Each year we pro…
The present book provides guidance to understanding complicated coupled processes based on the experimental data available and implementation of developed algorithms in numerical codes. Results of selected test cases in the fields of closed-form solutions (e.g., deformation processes), single processes (such as groundwater flow) as well as coupled processes are presented. It is part of the O…