Dear Colleagues, Malignant tumors develop distant metastases, e.g., small clusters of cells that detach from the primitive site and colonize distant organs and tissues. Unlike the primary masses, metastases are often difficult to fully eradicate by surgery ablation and are almost always the primary object of chemo- and/or immune-therapies. The presence of metastases at tumor diagnosis is respon…
This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determi…
This book (an updated and extended edition) is about mobilizing women and health care policy makers and providers to unite their efforts in a single strategy for fighting cervical cancer worldwide. The objective of this strategy would be to reverse cervical cancer prevalence and mortality rates among all 2.4 billion women at risk and to achieve this goal within 10-15 years of implementation. Ce…
Well-Differentiated Malignancies: New Perspectives is devoted to an important topic in surgical pathology which is inadequately covered by currently available books. Well-differentiated malignancies are systematically addressed with an emphasis on the tissue/cell specific malignant atypia. The key features for each malignancy are extensively illustrated with high quality pictures from authorita…
Well-Differentiated Malignancies: New Perspectives is devoted to an important topic in surgical pathology which is inadequately covered by currently available books. Well-differentiated malignancies are systematically addressed with an emphasis on the tissue/cell specific malignant atypia. The key features for each malignancy are extensively illustrated with high quality pictures from authorita…
The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major or…
Management of bladder cancer provides a single, comprehensive reference source that incorporates all the latest information regarding bladder cancer. The text covers epidemiology and natural history of bladder cancer as well as latest findings regarding the genetics and molecular biology of the disease. Diagnostic and staging evaluation of both non-muscle invasive and invasive bladder cancer is…
The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen-receptor modulator tamoxifen was developed in the 1970s for the treatment of breast cancer, data on estrogen-receptor status were correlated with the treatment outcome. Based on a phase II study performed in patients with advanced breast cancer, published in 1976, the investigators concluded:“a h…
Thyroid cancer is the most common malignant endocrine tumor and is the seventh most common cancer seen in throughout out the world. The incidence of thyroid cancer has been increasing more rapidly than any other cancer in many of the cancer registries from different parts of the world. Although the majority of thyroid cancers have an indolent biological behaviour, different histological types …
This handbook is a concise practical guide for residents and general radiologists that will offer reliable assistance during the performance and reporting of multidetector row computed tomography and magnetic resonance imaging in patients with Liver Bile Ducts and Pancreas conditions. It is organized alphabetically, primarily according to disease or condition, permitting easy and fast consultat…