This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the [1+2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity. He then introduces the conjugation of the…
This thesis addresses the coordination chemistry and reactivity of copper and gold complexes with a focus on the elucidation of (i) the metal-mediated activation of σ-bonds and (ii) the migratory insertion reaction. Both processes are of considerable importance in organometallic chemistry, but remain elusive for Cu and Au complexes. In this work, the author contributes significant advances: Th…
The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials scie…
Synergetics is the quantitative study of multicomponent systems that exhibit nonlinear dynamics and cooperativity. This book specifically considers basic models of the nonlinear dynamics of molecular systems and discusses relevant applications in biological physics and the polymer sciences. Emphasis is placed on specific solutions to the dynamical equations that correspond to the coherent form…
Serves as a comprehensive introduction and overview of synaptic tagging and capture (STC) and covers the topic from molecular and cellular aspects to behavior. Circa 15 years ago the STC model was proposed to provide a conceptual basis for how short-term memories are transformed into long-term memories. Though the hypothesis remains unconfirmed due to technological limitations, the model is we…
This book focuses on recent advances in our understanding of the signal transduction pathway of ethylene, its interaction with other hormones and its roles in biological processes. It discusses at which point plants could have acquired ethylene signaling from an evolutionary perspective. Ethylene was the first gaseous hormone to be identified and triggers various responses in higher plants. Our…
The United Nations estimates that 4 billion people worldwide live outside the protection of the law. These people can be driven from their land, intimidated by violence, and excluded from society. This Open Access book is about community paralegals – sometimes called barefoot lawyers – who demystify law and empower people to advocate for themselves.
Antimicrobial resistance (AMR) kills, increases the costs of our health care, damages trade and economies, and threatens health security. The most recent studies show that in the European Union (EU) over 33 000 people die every year due to antibiotic-resistant bacteria; of which, 75% of these deaths are caused by health care-associated infections. This is a burden that is comparable to that of…
The idea of person-centred health systems is widely advocated in political and policy declarations to better address health system challenges. A person-centred approach is advocated on political, ethical and instrumental grounds and believed to benefit service users, health professionals and the health system more broadly.
The Bible's grand narrative about Israel's Exodus from Egypt is central to Biblical religion, Jewish, Christian, and Muslim identity and the formation of the academic disciplines studying the ancient Near East. It has also been a pervasive theme in artistic and popular imagination. Israel's Exodus in Transdisciplinary Perspective is a pioneering work surveying this tradition in unprecedented br…