In praise of imperfection: how life on our planet is a catalog of imperfections, errors, alternatives, and anomalies. In the beginning, there was imperfection, which became the source of all things. Anomalies and asymmetries caused planets to take shape from the bubbling void and sent light into darkness. Life on earth is a catalog of accidents, alternatives, and errors that turned out to wo…
The biological power of the placebo effect. The power of placebos to ameliorate symptoms has been with us for centuries. Western medicine today is finding it increasingly difficult to ignore the efficacy of placebos. In some clinical trials with placebos as controls, inert or sham replicas of active pharmaceutical drugs and even sham surgeries have been found to be as beneficial as the inter…
How the FDA was shaped by public health crises and patient advocacy, told against a background of the contentious hearings on the breast cancer drug Avastin. Food and Drug Administration approval for COVID-19 vaccines and the controversial Alzheimer's drug Aduhelm made headlines, but few of us know much about how the agency does its work. Why is the FDA the ultimate US authority on a drug's …
A lavishly illustrated guide to the magnum opus of the great seventeenth-century anatomist, master embalmer, artist, and collector of specimens. Frederik Ruysch (1638–1731) was a celebrated Dutch anatomist, master embalmer, and museologist. He is best remembered today for strange tableaux, crafted from fetal skeletons and other human remains, that flicker provocatively at the edges of scie…
How science is opening up the mysteries of the heart, revealing the poetry in motion within the machine. Your heart is a miracle in motion, a marvel of construction unsurpassed by any human-made creation. It beats 100,000 times every day—if you were to live to 100, that would be more than 3 billion beats across your lifespan. Despite decades of effort in labs all over the world, we have no…
A leading developmental psychologist proposes an evolutionary pathway to human psychological agency. Nature cannot build organisms biologically prepared for every contingency they might possibly encounter. Instead, Nature builds some organisms to function as feedback control systems that pursue goals, make informed behavioral decisions about how best to pursue those goals in the current situ…
Stories from the ER: a doctor shows how empathy, creativity, and imagination are the cornerstones of clinical care. To be an emergency room doctor is to be a professional listener to stories. Each patient presents a story; finding the heart of that story is the doctor's most critical task. More technology, more tests, and more data won't work if doctors get the story wrong. When caring for o…
The second edition of this book updates and expands upon a historically important collection of mathematical problems first published in the United States by Birkhäuser in 1981. These problems serve as a record of the informal discussions held by a group of mathematicians at the Scottish Café in Lwów, Poland, between the two world wars. Many of them were leaders in the development of such ar…
This book provides an introduction to elementary probability and to Bayesian statistics using de Finetti's subjectivist approach. One of the features of this approach is that it does not require the introduction of sample space – a non-intrinsic concept that makes the treatment of elementary probability unnecessarily complicate – but introduces as fundamental the concept of random numbers d…
By bringing together top-notch demographers, sociologists, economists, statisticians and public health specialists from Asia, Africa, Europe, and North America to examine a wide variety of public and private issues in applied demography, this book spans a wide range of topics. It evaluates population estimates and projections against actual census counts and suggests further improvement of esti…