Familiarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand form…
This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, a…
Chronic stress induces structural and hormonal changes in the various brain structures: caudate nucleus, putamen, hippocampus, amygdala, prefrontal cortex in participants with post‐traumatic stress disorder. Based on the results of recent neuroimaging studies on post‐traumatic stress disorder, hippocampus, amygdala, and prefrontal cortex play a key role in triggering the typical symptoms of…
Stress-induced alterations in sleep have been linked to the development of post-traumatic stress disorder (PTSD) and sleep complaints and disturbances in arousal are continuing symptoms in patients. PTSD-related changes in sleep have not been fully characterized but involve persistent disturbances in both rapid eye movement sleep (REMS) and non-rapid eye movement sleep (NREMS). PTSD is consider…
Psychosocial Intervention for Co-Existing MDD and PTSD
Several psychotherapeutic treatments have been developed over the years for treating the symptoms of post-traumatic stress disorder (PTSD). But it remains still unclear which components of the complex treatment packages are necessary and most beneficial for PTSD symptom improvement. In PTSD outcome research, the randomized controlled trial (RCT) design has been applied in order to address this …
The Pharmacological Frontiers in Treatment Resistant Major Depression
We investigated personality traits, coping strategies, and social factors among emergency rescuers of three different catastrophic events that occurred in 2009 and 2013. These events were natural disasters, two of which were caused by human negligence. We used the cognitive interview (CI) protocol to interview witnesses and investigate their memory of the event. A qualitative analysis using the…
Neurobiological Background of Affective Disorders
A Journey Through Schizophrenia