Supercomputing facilities are becoming increasingly available in neuroscience, predominantly for simulating the dynamics of electrical activity propagating through neuronal circuits. On today's most advanced supercomputers, large-scale models can be simulated with up to a billion of neurons. However, merely further increasing the number of neurons and synapses will not be sufficient to create b…
The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological d…
This book is at the cutting edge of the ongoing ‘neo-Schumpeterian’ research program that investigates how economic growth and its fluctuation can be understood as the outcome of a historical process of economic evolution. Much of modern evolutionary economics has relied upon biological analogy, especially about natural selection. Although this is valid and useful, evolutionary economists h…
Lung cancer is the leading cause of mortality worldwide, with a low survival rate. Carcinogenesis generally requires a constellation of entwined steps, involving both innate cellular and environmental factors. This book shares the updated knowledge on the origin and development of cancer through genotypic changes which upset the physiological balance between cell proliferation, differentiation,…
In 2013 the European Commission launched its legislative proposal to create a European Public Prosecutor’s Office. The proposal provoked fierce debates, politically as well as on the academic level. Many national parliaments opposed and submitted formally their grievances to the Commission. Negotiations on the proposal between Member States are still ongoing. The T.M.C. Asser Instituut held t…
This handbook is a practical, easy-to-use reference that offers step-by-step instruction on ultrasound-guided interventional procedures for treatment of musculoskeletal pain of the lower limb. Each chapter is clearly structured and starts by offering a brief but comprehensive description of the disease to be treated that covers aspects such as epidemiology, etiology, clinical presentation and u…
Ultrasound in the Intensive Care Unit explores the current state of evidence supporting use of bedside ultrasound for procedural guidance and for the critical care-focused assessment of a variety of organ systems. This text covers standard practice areas, such as ultrasound guidance for vascular access in the ICU, as well as novel, less well-known applications such as the use of ultrasound for …
Focusing on technical, policy and social/societal practices and innovations for electrified transport for personal, public and freight purposes, this book provides a state-of-the-art overview of developments in e-mobility in Europe and the West Coast of the USA. It serves as a learning base for further implementing and commercially developing this field for the benefit of society, the environme…
This book takes a close look at macroeconomic imbalances within the Eurozone and explores the profound consequences the introduction of the European Monetary Union (EMU) has had on Euro area countries. Particular attention is given to balance of payments deficits and surpluses, and the profound difficulties of rebalancing the Euro area. Throughout the chapters, the author argues that the EMU ha…
This book presents a history of queer erasure in the US public school system, from the 1920s up until today. By focusing on specific events as well as the context in which they occurred, Lugg presents a way forward in improving school policies for both queer youth and queer adults.