Squamous cell carcinoma remains a significant cause of morbidity and mortality. It is a heterogeneous disease with complex molecular abnormalities. Head and neck squamous cell carcinomas (SCC) represent the most frequent human solid tumors and are a major cause of cancer mortality. Highly heterogeneous tumors arise from closely interconnected epithelial cell populations whose intrinsic self-ren…
Oral healthcare deals with complete oral health, including prevention, treatment, and cure. This book provides readers with the latest updates on dental clinical concepts and practical management techniques. It is divided into four sections that contain in-depth chapters with concepts and techniques from the fields of oral medicine, periodontology, radiology, endodontics, restorative dentistry,…
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectru…
Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alo…
The fields of cyberpsychology, e-health and virtual reality have evolved during the last 20 years and this Special Issue is devoted to recent developments in the understanding and treatment of psychological and mental disorders. Researchers have studied how mental health can be delivered online decades before the COVID-19 pandemic. This knowledge suddenly became invaluable when professionals ha…
Stereotactic radiosurgery is a relatively recent radiation technique initially developed using a frame-based system in 1949 by a Swedish neurosurgeon, Lars Leksell, for lesions not amendable to surgical resection. Radiosurgery is founded on principles of extreme radiation dose escalation, afforded by precise dose delivery with millimeter accuracy. Building upon the success of frame-based radios…
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
The first section of the book entitled Clinical and Molecular Advances in Ankylosing Spondylitis is a review of the clinical manifestations of Ankylosing Spondylitis (AS) and Spondyloarthritis (SpA). The book includes chapters on Bone Mineral Density measurements, two chapters on the temporomandibular joints, axial fractures, clinical manifestations, diagnosis, and treatment. Molecular genetics…
This book on Epilepsy was conceived and produced as a source of information on wide range of issues in epilepsy. We hope that it will help health care providers in daily practices and increase their understanding on diagnosis and treatment of epilepsies. The book was designed as an update for neuroscientists who are interested in epilepsy, primary care physicians and students in health care pro…