This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcript…
This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the…
Many patients with pulmonary complaints fail to improve despite physicians’ best efforts. Sometimes, we ascribe this failure to lack of adherence with therapy, or to the severity of the condition. What we often fail to appreciate, however, is that sometimes the lack of improvement can be explained by the patients' psychological states. The first section of Functional Respiratory Disorders: W…
This pocket manual is designed to guide medical professionals in acquiring skills in basic ultrasound imaging. It describes the most common scans performed at the patient’s bedside, specifically in the emergency department or intensive care unit. Following an overview of basic ultrasound principles, the use of this modality to visualize specific organ systems is described. In a quick-referenc…
This work presents the first comprehensive and systematic treatment of all relevant issues and topics in contemporary global bioethics. Now that bioethics has entered into a novel global phase, a wider set of issues, problems and principles is emerging against the backdrop of globalization and in the context of global relations. This new stage in bioethics is furthermore promoted through the et…
This open access book investigates psychiatry in Uganda during the years of decolonisation. It examines the challenges facing a new generation of psychiatrists as they took over responsibility for psychiatry at the end of empire, and explores the ways psychiatric practices were tied to shifting political and development priorities, periods of instability, and a broader context of transnational …
This book describes the pathophysiological significance of the hemodynamic monitoring parameters available to the clinician and their role in providing reliable and reproducible information on the cardiocirculatory status of a patient in shock. It is explained how measurements of these parameters enable the intensivist to understand the patient’s condition and to make more informed treatment …
This book discusses the common principles of morality and ethics derived from divinely endowed intuitive reason through the creation of al-fitr' a (nature) and human intellect (al-‘aql). Biomedical topics are presented and ethical issues related to topics such as genetic testing, assisted reproduction and organ transplantation are discussed. Whereas these natural sources are God’s specia…
This book presents a collection of short biographies and works of the pioneers in pathology. The alphabetically arranged entries allow readers to quickly and easily find the information they need.
This book brings together two important discussions in public health in developing countries: an understanding of the burden of disease, health equity and social determinants of health; and biomathematical models, epidemiological studies and estimation of the direct and indirect cost of disease. The empirical chapters in the first part discuss aspects of disease prevention and health promotion …