Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to AÅ
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kina…
As a new conservation paradigm, rewilding is quickly gaining popularity across Scotland. Against the urgencies of the Anthropocene, rewilding projects offer hope by imagining radical visions of biodiverse futures that promise liveability not just to humans but a large host of species. Based on multi-sited ethnographic fieldwork conducted in Scotland, this study explores the diverse multispecies…
The life of proteins starts and ends as amino acids. In addition to the primary function as protein building blocks, amino acids serve multiple other purposes to make a plant's life worth living. This is true especially for the amino acids of the glutamate family, namely glutamate (Glu), glutamine (Gln), proline (Pro) and arginine (Arg), as well as the product of Glu decarboxylation, ?-aminobut…
This reprint is based on “Antimicrobial resistance and anti-biofilms” in the journal Antibiotics since November of 2020. This reprint has one editorial article, eight research articles, one review article, and one case report article, covering a time period of 15 months from December of 2021 to February of 2023. Containing three major sub-topics in this reprint, four manuscripts regarding t…
Gulf stability is coming to play a larger role in the foreign policy calculus of many states, but the evolving role of Asian powers is largely under-represented in the International Relations literature. This volume addresses this gap with a set of empirically rich, theory driven case studies written by academics from or based in the countries in question. The underlying assumption is not that …
This volume collects the contributions presented at the conference “Data-driven Decision Making” organized by the Italian Association for Applied Statistics, held in Genoa from 12 to 14 September 2022. The papers cover a broad range of topics, with a common thread: the use of statistical methods to support decision-making both in public administrations and in private companies.
This e-book focuses primarily on the role of the fornix as a functional, prognostic, and diagnostic marker of Alzheimer's disease (AD), and the application of such a marker in clinical practice. Researchers have long been focused on the cortical pathology of AD, since the most important pathologic features are the senile plaques found in the cortex, and the neurofibrillary tangles and neuronal …