Written and edited by leading, internationally recognized clinicians and scientists in reproductive medicine and related fields, this unique text is a practical and comprehensive review of the clinical and scientific significance of unexplained male and female infertility and its management. The book is divided into thematic sections to ensure the most useful presentation of topics, opening wit…
Personalized medicine is presented as the future of patient care. Nuclear Medicine will play a major role in the selection of patients for targeted therapies and in early therapy assessment with the investigation of phenotypes and functions using sensitive and specific SPECT and PET imaging techniques and theranostic approaches. Nuclear Medicine is already a key in the development of new therap…
Supercomputing facilities are becoming increasingly available in neuroscience, predominantly for simulating the dynamics of electrical activity propagating through neuronal circuits. On today's most advanced supercomputers, large-scale models can be simulated with up to a billion of neurons. However, merely further increasing the number of neurons and synapses will not be sufficient to create b…
The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological d…
Ultrasound of the Male Genitalia presents a comprehensive, evidence based reference as well as a practical guide for the performance and interpretation of the male genital ultrasound examination. The volume begins with the history of male genital ultrasound and includes a discussion of regulations surrounding the performance of ultrasound examinations by urologists. The book provides a comprehe…
This book provides an overview of the current state-of-art in combining advances in biomedical imaging with intraoperative navigation and preoperative planning for urologic surgery. These advances hold great promise in improving diagnostic and therapeutic urologic interventions to improve patient outcomes. Leading experts in this exciting emerging field covers early clinical and pre-clinical ap…
Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson's Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a his…
The way you perceive the world, plan, make decisions and communicate your thoughts and feelings depends on the function and hierarchical arrangement of cortical modules. The ability to both provide adaptive responses to our ever-changing environment and to pursue a useful role in society is the most important problem faced by present day neuroscientists. In essence, the workings of cortical mo…
Laparoscopic colectomy has been introduced in the early 90ies as a new technique with proven improvement in short and long term outcome. Despite significant patient benefits the overall adoption rate remains low. On the other hand significant more advanced techniques such as single incision laparoscopy, robotics and transanal access surgery have been introduced in the last several years and are…
This cutting-edge book will cover various aspects of headache management, with a focus on difficult patients. Practical, step-by-step advice for treating challenging headaches, including migraine, refractory and cluster headaches, will be provided in detail along with how to approach patients of different ages and those with psychological disorders. Unique and complex case studies and complet…