Reviews the most intriguing applications of fractal analysis in neuroscience with a focus on current and future potential, limits, advantages, and disadvantages. Will bring an understanding of fractals to clinicians and researchers also if they do not have a mathematical background, and will serve as a good tool for teaching the translational applications of computational models to students and…
Our understanding of human color vision has advanced tremendously in recent years, helped along by many new discoveries, ideas, and achievements. It is therefore timely that these new developments are brought together in a book, assembled specifically to include new research and insight from the leaders in the field. Although intentionally not exhaustive, many aspects of color vision are discus…
Personalized medicine is presented as the future of patient care. Nuclear Medicine will play a major role in the selection of patients for targeted therapies and in early therapy assessment with the investigation of phenotypes and functions using sensitive and specific SPECT and PET imaging techniques and theranostic approaches. Nuclear Medicine is already a key in the development of new therap…
Supercomputing facilities are becoming increasingly available in neuroscience, predominantly for simulating the dynamics of electrical activity propagating through neuronal circuits. On today's most advanced supercomputers, large-scale models can be simulated with up to a billion of neurons. However, merely further increasing the number of neurons and synapses will not be sufficient to create b…
The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological d…
This book is at the cutting edge of the ongoing ‘neo-Schumpeterian’ research program that investigates how economic growth and its fluctuation can be understood as the outcome of a historical process of economic evolution. Much of modern evolutionary economics has relied upon biological analogy, especially about natural selection. Although this is valid and useful, evolutionary economists h…
Lung cancer is the leading cause of mortality worldwide, with a low survival rate. Carcinogenesis generally requires a constellation of entwined steps, involving both innate cellular and environmental factors. This book shares the updated knowledge on the origin and development of cancer through genotypic changes which upset the physiological balance between cell proliferation, differentiation,…
In 2013 the European Commission launched its legislative proposal to create a European Public Prosecutor’s Office. The proposal provoked fierce debates, politically as well as on the academic level. Many national parliaments opposed and submitted formally their grievances to the Commission. Negotiations on the proposal between Member States are still ongoing. The T.M.C. Asser Instituut held t…
This handbook is a practical, easy-to-use reference that offers step-by-step instruction on ultrasound-guided interventional procedures for treatment of musculoskeletal pain of the lower limb. Each chapter is clearly structured and starts by offering a brief but comprehensive description of the disease to be treated that covers aspects such as epidemiology, etiology, clinical presentation and u…
Ultrasound in the Intensive Care Unit explores the current state of evidence supporting use of bedside ultrasound for procedural guidance and for the critical care-focused assessment of a variety of organ systems. This text covers standard practice areas, such as ultrasound guidance for vascular access in the ICU, as well as novel, less well-known applications such as the use of ultrasound for …