The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
This book presents lessons learnt from Japan’s past, in relation to coastal waters, industrial pollutants and concentrated urban populations. It examines ecosystem damage and pollution in coastal sea areas and addresses the question: What is the present status of Japanese estuaries from the view point of eutrophication and oligotrophication? The authors describe three typical situations, name…
This book provides clear instruction on the surgical treatment of joint problems in adult hemophilia patients. The procedures applicable to specific joints, including the shoulder, elbow, hip, knee and ankle, are carefully reviewed with the aid of high-quality illustrations. The surgical treatment of articular hemophilic pseudotumors and bone cysts is also considered. In addition, clinically re…
This book celebrates the 100th birthday of Jerome S. Bruner, one of the most relevant scholars in contemporary psychology. It shows how Bruner’s oeuvre and contributions to psychology, education and law are still applicable today and full of unexplored possibilities. The volume brings together contributions from Bruner’s students and colleagues, all of whom use his legacy to explore the fut…
This Atlas presents records of climatic variability and change in Europe starting before 1901 and focuses especially on trends of extreme temperatures and precipitation. The authors have used software developed within EMULATE (European and North Atlantic daily to MULtidecadal climATE variability) to obtain the extremes indices and temporal trends. The trend atlas provides an easy way to identif…
This anthology highlights the theoretical foundations as well as the various applications of Behavioural Law and Economics in European legal culture. By the same token, it fosters the dialogue between European and American Law and Economics scholars. The traditional neo-classical microeconomic theory explains human behaviour by using Rational Choice. According to this model, people tend to m…
The work addresses the following questions in the context of interglacial climate dynamics: (i) What are the amplitudes of natural climate variations on timescales of several years to millennia? (ii) Do abrupt changes in the large-scale circulation of the Atlantic Ocean occur in interglacials? (iii) Which biogeochemical feedback mechanisms control the natural limits of atmospheric concentration…
This book summarizes results of longstanding research and scientific contributions from many projects and relevant working groups. It collects and evaluates wind and wave climate projections under changing climate having design needs and marine safety in focus. Potential impact of projected climate change in met-ocean conditions on ships and offshore structures is discussed and illustrated by a…
In this monograph, the authors present a modern development of Euclidean geometry from independent axioms, using up-to-date language and providing detailed proofs. The axioms for incidence, betweenness, and plane separation are close to those of Hilbert. This is the only axiomatic treatment of Euclidean geometry that uses axioms not involving metric notions and that explores congruence and isom…
The SpringerBriefs on Atmospheric and Space Sciences in two volumes presents a concise and interdisciplinary introduction to the basic theory, observation & modeling of atmospheric and ionospheric coupling processes on Earth. The goal is to contribute toward bridging the gap between meteorology, aeronomy, and planetary science. In addition recent progress in several related research topics, suc…