Twentieth
The idea of combining drugs and diagnostics in oncology is not new. When the selective estrogen-receptor modulator tamoxifen was developed in the 1970s for the treatment of breast cancer, data on estrogen-receptor status were correlated with the treatment outcome. Based on a phase II study performed in patients with advanced breast cancer, published in 1976, the investigators concluded:“a h…
Power transformers are key components in electric power distribution and transmission systems, and it is essential that they function properly for many years. With increasing age, there are potential risks of extremely high monetary losses due to unexpected failures and outages. A simple solution would be to replace all aging and risky transformers at once with new ones. Such an approach is obv…