The immune system detects "danger", through a series of what we now call damage associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. DAMPS also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory…
This book concisely but thoroughly summarizes advances in understanding of the spectrum of orbital inflammatory disorders that have resulted from recent basic and clinical research and explains their significance for clinical practice. The full range of inflammatory disorders is considered, including bacterial and fungal infections, IgG4-related orbital inflammation, sarcoidosis, Sjögren’s s…