The combinatorial number of possible methylomes in biological time and space is astronomical. Consequently, the computational analysis of methylomes needs to cater for a variety of data, throughput and resolution. Here, we review recent advances in 2nd generation sequencing (2GS) with a focus on the different methods used for the analysis of MeDIP-seq data. The challenges and opportunities pres…
This book offers a provocative account of interdisciplinary research across the neurosciences, social sciences and humanities. Setting itself against standard accounts of interdisciplinary 'integration,' and rooting itself in the authors' own experiences, the book establishes a radical agenda for collaboration across these disciplines. Rethinking Interdisciplinarity does not merely advocate int…
The nutritional biochemist Alfred E. Harper was a member of the Food and Nutrition Board of the National Research Council/National Academy of Sciences for many years, and chair of the Food and Nutrition Board from 1978 to 1982. The scientific bases for many Recommended Dietary Allowances (RDA) were prevention of deficiency with a margin of safety, often determined from depletion-repletion studi…
Rabbit livestock is especially important in the Mediterranean area and in the semi-arid zones of Africa, Asia, and America, representing a valuable alternative source of good animal protein of high quality (low fat and low cholesterol). However, rabbit husbandry should adapt to be a competitive and sustainable sector. In addition, it must maintain a balance between rabbit welfare, customer dema…
Ageing populations pose some of the foremost global challenges of this century. Drawing on an international pool of scholars, this cutting-edge Handbook surveys the micro, macro and institutional aspects of the economics of ageing. Structured in seven parts, the volume addresses a broad range of themes, including health economics, labour economics, pensions and social security, generational acc…
Biogenic amines have been known for some time. These compounds are found in varying concentrations in a wide range of foods (fish, cheese, meat, wine, beer, vegetables, etc.) and their formations are influenced by different factors associated to those foods (composition, additives, ingredients, storage, microorganism, packaging, handing, conservation, etc.). The intake of foods containing high …
This open access book is the first comprehensive guideline for the beryllium-7 (Be-7) technique that can be applied to evaluate short-term patterns and budgets of soil redistribution in agricultural landscapes. While covering the fundamental and basic concepts of the approach, this book distinguishes itself from other publications by offering step-by-step instructions on how to use this isotopi…
Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kina…
This reprint is based on “Antimicrobial resistance and anti-biofilms” in the journal Antibiotics since November of 2020. This reprint has one editorial article, eight research articles, one review article, and one case report article, covering a time period of 15 months from December of 2021 to February of 2023. Containing three major sub-topics in this reprint, four manuscripts regarding t…