
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…

An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular technique…

The purpose of this SI is to provide an overview of recent advances made in the methods used for tissue imaging and characterization, which benefit from using a large range of optical wavelengths. Guerouah et al. has contributed a profound study of the responses of the adult human brain to breath-holding challenges based on hyperspectral near-infrared spectroscopy (hNIRS). Lange et al. contribu…

Pain biomarkers are biological indicators or measurable characteristics that can provide information about the presence, severity, or underlying mechanisms of pain. They are valuable for several reasons: Diagnosis and differential diagnosis: Biomarkers can help in the diagnosis of various pain conditions and differentiate between different types of pain, such as neuropathic, inflammatory, or no…

Stringent ways of thinking, ‘conceptual frameworks’, are necessary in science. The drawback is that the associated assumptions, concepts, rules and practice may become so deeply entrenched that they turn into tacit knowledge and hence give rise to constraints in scientific thought and practice – that is, a new kind of plethora that seriously blinds and thereby hampers scientific progress.…

The commonness and complexity of COPD necessitate rapid communication of significant new knowledge of the disease. This book provides a platform for sharing new notions in scientific research as well as contemporary clinical best practices. It combines noetic theoretical concepts with the ontic practical management of COPD. Epistemological concepts explored in this book include contextualizatio…

This reprint is about vitamin D, a molecule that can be absorbed from certain foods, such as fatty fish, which can also be produced endogenously when we expose our skin to sufficient doses of ultraviolet B radiation. When vitamin D is metabolized into 1,25(OH)2D3 (also called calcitriol), it acts as a high-affinity ligand for the transcription factor VDR, i.e., it has direct effects on gene reg…
This Special Issue of the International Journal of Molecular Science comprises a comprehensive study on "Metal Complex Interactions with Nucleic Acids and/or DNA". This Special Issue has been inspired by the important contribution of Prof. Nick Hadjiliadis to the field of palladium or/and platinum/nucleic acid interactions. It covers a selection of recent research and review articles in the fie…

