AI promises major benefits for healthcare. But along with the benefits come risks. Not so much the risk of powerful super-intelligent machines taking over, but the risk of structural injustices, biases, and inequalities being perpetuated in a system that cannot be challenged because nobody actually knows how the algorithms work. Or, the risk that there might be no doctor or nurse present to hol…
The huge prevalence of type 2 diabetes is a leading human and economic concern worldwide. The diagnosis code of type 2 diabetes includes multiple clinical phenotypes showing different degrees of obesity, fat distribution patterns, types of dyslipidemia, and characteristics of insulin resistance syndrome. In addition, subjects with type 2 diabetes could develop different clinical trajectories, w…
In this Special Issue, our aim was to collect studies on clinical pharmacology and pharmacy of antimicrobial agents from both human and veterinary medicine as the complex problem of AMR requires actions taken within the One Health approach that involve both fields. Studies covered here are about new or optimized usage of already authorized antimicrobials, as well as discoveries about new agents…
Trauma is still a leading cause of death in patients below 40 years of age. Clinical management of severely injured patients is challenging in all phases of treatment during the clinical course. Numerous factors, such as injury severity, injury pattern, patient characteristics and trauma system, affect the decision-making process in our patients. After the successful initial management of an un…
This reprint "Clinical Features of COVID-19 in Elderly Patients" is a crucial resource dedicated to the medical challenges posed by the pandemic, with a specific focus on its impact on elderly people. Given their vulnerability, understanding the clinical aspects of COVID-19 in this demographic is paramount. This reprint compiles a wide array of studies and current knowledge tailored to address …
systemic lupus erythematosus; quality of life; cross-sectional studies; surveys and questionnaires; rheumatoid arthritis; fatigue; pain; psychosocial; disease activity; health-related quality of life; patient-reported outcomes; clinical follow-up; outcome measures; abnormal liver function tests; autoimmune liver diseases; autoimmune hepatitis; hepatic involvement; liver biopsy; primary biliary …
Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alo…
Stereotactic radiosurgery is a relatively recent radiation technique initially developed using a frame-based system in 1949 by a Swedish neurosurgeon, Lars Leksell, for lesions not amendable to surgical resection. Radiosurgery is founded on principles of extreme radiation dose escalation, afforded by precise dose delivery with millimeter accuracy. Building upon the success of frame-based radios…
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
Across the social sciences and even in philosophy, trust is most often characterized in terms of expectations and probabilities. This book defends an alternative conception of trust as a moral phenomenon. When one person trusts another to do something, the first relies on the second's commitment(s). So, trust reflects-and is a product of-agreement about the commitments and obligations that b…