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Spider Venoms
This volume provides an overview of the biochemical characterization, structure-function studies, proteomics, bioinformatics, molecular biology, transcriptomics and genomics of various spider species. The book also covers our current knowledge of venom components, toxins and their modes of action. The first section of Spider Venom includes contributions regarding the wide diversity of spider ve…
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- 978-94-007-6389-0
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Venom Genomics and Proteomics
This volume provides the reader with recent advances in the fields of molecular toxinology, the biotechnological applications of venom toxins, and antivenom production. The content of the twenty chapters of Venom Genomics and Proteomics illustrates not only the enormous progress made since the implementation of omics technologies in the field of toxinology, but one also realizes the road still …
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- 978-94-007-6416-3
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Validation of Alternative Methods for Toxicity Testing
This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcript…
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- 978-3-319-33826-2
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Approaching China's Pharmaceutical Market: A Fundamental Guide to Clinical Dr…
This authoritative volume examines the major laws, regulations and guidelines related to pharmaceutical product development in China. With a focus on patent, clinical and registration strategies, the book helps Western companies introduce their clinical drugs to the Chinese market, determine a strategic path and bridge the gap for regulatory and legal differences between China and the Wester…
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- Ed. 1
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- 978-3-319-15576-0
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- XVI, 648
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- 615.19 APP a
Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug…
The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin …
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- 978-1-4471-4920-0
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Translating Molecular Biomarkers into Clinical Assays Techniques and Applica…
This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are …
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- 978-3-319-40793-7
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Transglutaminases Multiple Functional Modifiers and Targets for New Drug Dis…
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although se…
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- 978-4-431-55825-5
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Formulating Poorly Water Soluble Drugs
The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physio…
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- 978-3-319-42609-9
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- XIV, 779 pages
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- AAPS Advances in the Pharmaceutical Sciences Series
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