Published in 1977, this collection of essays was published to honor Cratis D. Williams upon his retirement from Appalachian State University. Williams was an influential scholar, folklorist, teacher, and administrator who spent much of his career focused on the Appalachian region. Edited by J. W. Williamson, contributors to the volume are Louie Brown, Ronald J. Eller, Alan J. Crain, Stephen Fis…
The philosophy on which the Marine Corps' seminal warfighting doctrine is based rests on a tradition of professional military scholarship that reaches back to Carl von Clausewitz's treatise On War. Clausewitz's lesser-known and often-misunderstood Guide to Tactics, republished here for the first time as a standalone English text with critical annotations, serves as the foundation of the Marine …
This open access book addresses a variety of issues relating to bioethics, in order to initiate cross-cultural dialogue. Beginning with the history, it introduces various views on bioethics, based on specific experiences from Japan. It describes how Japan has been confronted with Western bioethics and the ethical issues new to this modern age, and how it has found its foothold as it decides whe…
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer's disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to AÅ
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researcher…
Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kina…
As a new conservation paradigm, rewilding is quickly gaining popularity across Scotland. Against the urgencies of the Anthropocene, rewilding projects offer hope by imagining radical visions of biodiverse futures that promise liveability not just to humans but a large host of species. Based on multi-sited ethnographic fieldwork conducted in Scotland, this study explores the diverse multispecies…
The life of proteins starts and ends as amino acids. In addition to the primary function as protein building blocks, amino acids serve multiple other purposes to make a plant's life worth living. This is true especially for the amino acids of the glutamate family, namely glutamate (Glu), glutamine (Gln), proline (Pro) and arginine (Arg), as well as the product of Glu decarboxylation, ?-aminobut…
Emphatically revisionist, Bob Pepperman Taylor reveals a Thoreau most people never knew existed. Contrary to conventional views, Taylor argues that Thoreau was one of America's most powerful and least understood political thinkers, a man who promoted community and democratic values, while being ever vigilant against the evils of excessive or illegitimate authority.Still widely viewed as a remar…