The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in m…
This book provides a thorough introduction to the mathematical and algorithmic aspects of certified reduced basis methods for parametrized partial differential equations. Central aspects ranging from model construction, error estimation and computational efficiency to empirical interpolation methods are discussed in detail for coercive problems. More advanced aspects associated with time-depend…
In the second half of the eighteenth century, the English philologist Nathaniel Brassey Halhed (1751–1830) was employed in India by the East India Company. There he was asked to translate into English the Hindu legal code, so that the British authorities could better understand native laws. The result was this accomplished work, first published in 1776, which served to correct Western misinte…
This Brief provides a comprehensive introduction to the control of blood flow in the brain. Beginning with the basic physiology of autoregulation, the author goes on to discuss measurement techniques, mathematical models, methods of analysis, and relevant clinical conditions, all within this single volume. The author draws together this disparate field, and lays the groundwork for future resear…
This volume presents the revised lecture notes of selected talks given at the Fifth Central European Functional Programming School, CEFP 2013, held in July 2013 in Cluj-Napoca, Romania. The 14 revised full papers presented were carefully reviewed and selected. The lectures cover a wide range of distributed and multicore functional programming subjects. The last 5 papers are selected papers of t…
Author and activist Helen Hunt Jackson (1830–85) is remembered for her work in support of Native American rights. She was also a friend and correspondent of the poet Emily Dickinson, and her own verse was praised by Ralph Waldo Emerson. Her highly popular novel Ramona (1884) addressed discrimination against Native Americans, raising public consciousness as Harriet Beecher Stowe had done for s…
This book aims to provide knowledge on how infrastructure is planned and built in a typical developing country, and what key variables are there in the system limiting the efficient use of public investments in infrastructure. The book begins with a comprehensive literature review on construction and economic development, and trade and economic development. The focus of the book is on the case …
Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials…
The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the foc…
Much of what is known about the universe came from the study of celestial shadows. This book looks in detail at the way eclipses and other celestial shadows have given us amazing insights into the nature of the objects in our solar system and how they are even helping us discover and analyze planets that orbit stars other than our Sun. A variety of eclipses, transits, and occultations of the mo…