Pioglitazone has been reported in the literature to have a substantial role in the improvement of overall cognition in a mouse model. With this in mind, the aim of this study was to determine the most efficacious route for the administration of Pioglitazone nanoparticles (PGZ-NPs) in order to promote drug delivery to the brain for the treatment of Alzheimer’s disease. PGZ-loaded NPs were …
Precipitation is the most important variable in the climate system and the dominant driver of land surface hydrologic conditions. Rain gauge measurement provides precipitation estimates on the ground surface; however, these measurements are sparse, especially in the high-elevation areas of Nepal. Reanalysis datasets are the potential alternative for precipitation measurement, although it mu…
Although fluid dynamics, a classical discipline, has been studied for many centuries, there are still many remaining questions yet to be answered, especially in turbulent flow. With significant advances in computational technology and decrease hardware costs, we have noticed a rapid evolution in CFD techniques and models
: A Ho:YVO4 laser double-pass-pumped with a 1.91 μm wavelength-stabilized laser diode is presented in this paper. The maximum output power was up to 8.7 W, with a wavelength of 2052.4 nm and a slope efficiency of 37.4%. The
Lab-on-a-Disc (LoaD) biosensors are increasingly a promising solution for many biosensing applications. In the search for a perfect match between point-of-care (PoC) microfluidic devices and biosensors, the LoaD platform has the potential to be reliable, sensitive, low-cost, and easy-to-use
Today, researchers are focused on studying and identifying new products that can be beneficial for both food and pharmaceutical purposes. In this context, sprouts and microgreens are widely recognized as functional foods due to their high nutritional value, and in particular, their high bioactive compound content, which is mainly composed of phytochemicals. However, despite extensive research o…
Discriminating multiphase methane (adsorbed and free phases) in coals is crucial for evaluating the optimal gas recovery strategies of coalbed methane (CBM) reservoirs. However, the existing volumetric-based adsorption isotherm method only provides the final methane adsorption result, limiting real-time dynamic characterization of multiphase methane in the methane adsorption process
With the end of Moore’s law in sight, new computing paradigms are needed to fulfill the increasing demands on data and processing potentials. Inspired by the operation of the human brain, from the dimensionality, energy and underlying functionalities, neuromorphic computing systems that are building upon circuit elements to mimic the neurobiological activities are good concepts to meet th…
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease and is considered a common pathway leading to end-stage of renal failure. Renal fibrosis involves a complex interplay between intrinsic kidney cells, leukocytes, and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. Inhibition of TGF-β1 suppresses renal fib…
Standard laboratory methods for measurement of soil nitrate (NO3–N) use various procedures and instruments to analyze soil samples taken from the field and transported to the laboratory