This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathol…
It remains unclear when and where Charles Darwin had his transformative idea of species evolution through random variation and selective retention. The legend goes that the fi rst inklings of the idea came to him on board the Beagle during the ship’s visit to the Galapagos Islands in the Eastern Pacifi c. Here he beheld fi nches with differently shaped beaks, which suggested local adaptat…