This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics. A multidisciplinary group of experts in Genetics, Dermatology, Pathology, and Melanoma Medical Oncology contribute state-of-the-art knowledge in melanoma research and clinical management, not only exposing the current status of knowledge …
This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrin…
This book constitutes the refereed proceedings of the 13th International Conference on Computational Methods in Systems Biology, CMSB 2015, held in Nantes, France, in September 2015. The 20 full papers and 2 short papers presented were carefully reviewed and selected from 43 full and 4 short paper submissions. The papers cover a wide range of topics in the analysis of biological systems, networ…
This volume contains the best papers presented at the 2nd ECCOMAS International Conference on Multiscale Computations for Solids and Fluids, held June 10-12, 2015.
This book explains how to use intravitreal steroids optimally in the management of patients with intraocular inflammation (uveitis) and macular edema. The rationale for this treatment approach is first explained by examining the pathophysiology of these disease entities, with particular attention to the major role of inflammatory processes. Devices for the delivery of steroids to the eye are di…
This book contributes to the enhancement of fundamental and practical knowledge in the treatment of fractures, healing disturbances and bone disorders with intramedullary nailing. It promotes this biological and mechanical outstanding technique for appropriate indications and ameliorate the standard of care for those patients, who can profit from intramedullary nailing. Orthopedic trauma surgeo…
This book highlights participatory video as an instrument for community-based adult education and focuses in particular on the role that it can play in promoting participatory culture among adult learners. In brief, participatory video refers to participant-centered video making. Today, participant-generated videos can travel farther and faster than ever before, and thus, the perspectives repre…
A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above …
This book constitutes the refereed proceedings of the 6th International Conference on Computational Logistics, ICCL 2015, held in Delft, The Netherlands, in September 2015. The 50 papers presented in this volume were carefully reviewed and selected for inclusion in the book. They are organized in topical sections entitled: transport over ground, transport over water, international coordination …