The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of …
The aim of this book is to advocate and promote network models of linguistic systems that are both based on thorough mathematical models and substantiated in terms of linguistics. In this way, the book contributes first steps towards establishing a statistical network theory as a theoretical basis of linguistic network analysis the boarder of the natural sciences and the humanities. This book a…
Rear-Admiral James Burney (1750–1821), brother of the novelist Fanny Burney and son of the musicologist Dr Charles Burney, is best known for his five-volume compilation of voyages in the Pacific Ocean (also reissued in this series). He began his maritime career at the age of ten, as a captain's servant. Five years later he became a naval officer, and from 1772 to 1780 served on Cook's second …
In this volume, the author investigates and argues for, a particular answer to the question: What is the right way to logically analyze modalities from natural language within formal languages? The answer is: by formalizing modal expressions in terms of predicates. But, as in the case of truth, the most intuitive modal principles lead to paradox once the modal notions are conceived as predicate…
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock an…
This short work, featuring a number of attractive engravings, traces an abortive expedition to the Canadian Arctic. George Francis Lyon (1795–1832), naval officer and explorer, had accompanied William Parry on a previous expedition in search of the North-West Passage. In 1824 Lyon was instructed to return to Repulse Bay and to explore the mainland. Unfavourable weather conditions forced Lyon …
In this book, the author theoretically studies two aspects of topological states. First, novel states arising from hybridizing surface states of topological insulators are theoretically introduced. As a remarkable example, the author shows the existence of gapless interface states at the interface between two different topological insulators, which belong to the same topological phase. While…
This book brings together selected peer-reviewed contributions from various research fields in statistics, and highlights the diverse approaches and analyses related to real-life phenomena. Major topics covered in this volume include, but are not limited to, bayesian inference, likelihood approach, pseudo-likelihoods, regression, time series, and data analysis as well as applications in the…
This book highlights the latest research findings from the 46th International Meeting of the Italian Statistical Society (SIS) in Rome, during which both methodological and applied statistical research was discussed. This selection of fully peer-reviewed papers, originally presented at the meeting, addresses a broad range of topics, including the theory of statistical inference; data mining and…
In his works on ethics, Foucault turned towards an examination of one's relationship with oneself and others. This differs from the modern approaches that explore the relationship between and the responsibilities of actors to each other by adopting criteria. Ethical criteria engender assumptions about the actors by focusing on their responsibilities. Instead of relying on criteria, Foucault's w…