This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spec…
This book contains the outcome of the international meeting on instability, control and noise generated by massive flow separation that was organized at the Monash Center, in Prato, Italy, September 4-6, 2013. The meeting served as the final review of the EU-FP7 Instability and Control of Massively Separated Flows Marie Curie travel grant and was supported by the European Office of Aerospace…
This Brief addresses the phenomena of instability in flow boiling in microchannels occurring in high heat flux electronic cooling. A companion edition in the SpringerBrief Subseries on Thermal Engineering and Applied Science to “Critical Heat Flux in Flow Boiling in Microchannels,” and "Heat Transfer and Pressure Drop in Flow Boiling in Microchannels,"by the same author team, this volume is…
This book describes for the first time a simulation method for the fast calculation of contact properties and friction between rough surfaces in a complete form. In contrast to existing simulation methods, the method of dimensionality reduction (MDR) is based on the exact mapping of various types of three-dimensional contact problems onto contacts of one-dimensional foundations. Within the conf…
This book is the first volume of a two-volume set summarizing 40 years of key research findings directly related to metal-resistant Cupriavidus/Ralstonia (Betaproteobacteria). In this first volume, the historical and geographical context of these bacteria, which are mostly found in industrial and polluted environments linked to zinc and other non-ferrous metallurgy, is sketched to illustrate th…
This timely book deals with a current topic, i.e. the applications of metaheuristic algorithms, with a primary focus on optimization problems in civil engineering. The first chapter offers a concise overview of different kinds of metaheuristic algorithms, explaining their advantages in solving complex engineering problems that cannot be effectively tackled by traditional methods, and citing the…
This book constitutes the refereed proceedings of Satellite Events held at the 19th International Conference on Knowledge Engineering and Knowledge Management, EKAW 2014 in November 2014. EKAW 2014 hosted three satellite workshops: VISUAL 2014, International Workshop on Visualizations and User Interfaces for Knowledge Engineering and Linked Data Analytics, EKM1, the First International Workshop…
This book provides a synthesis of recent developments in Axiomatic Design theory and its application in large complex systems. Introductory chapters provide concise tutorial materials for graduate students and new practitioners, presenting the fundamentals of Axiomatic Design and relating its key concepts to those of model-based systems engineering. A mathematical exposition of design axioms is…
This volume discusses post-socialist urban transport functioning and development in Russia, within the context of the country’s recent transition towards a market economy. Over the past twenty-five years, urban transport in Russia has undergone serious transformations, prompted by the transitioning economy. Yet, the lack of readily available statistical data has led to a gap in the inclusion …
This textbook provides a thorough presentation of the phenomena related to the transport of mass, momentum and energy. It lays all the basic physical principles, then for the more advanced readers, it offers an in-depth treatment with advanced mathematical derivations and ends with some useful applications of the models and equations in specific settings. The important idea behind the book is …